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2.83 MB
Extraction Summary
4
People
4
Organizations
0
Locations
2
Events
2
Relationships
4
Quotes
Document Information
Type:
Article / publication excerpt (nautilus education)
File Size:
2.83 MB
Summary
This document is a page from a Nautilus Education publication (likely a magazine or educational material) marked with a House Oversight Bates stamp. It details scientific research into cancer treatment 'outliers' or exceptional responders, specifically focusing on a patient treated at Memorial Sloan-Kettering by Dr. Solit using the drug everolimus. The text discusses the genetic mutations (TSC1 and NF2) involved and describes a subsequent project launched by the National Cancer Institute, led by Barbara Conley, to identify similar cases in historical clinical trial data.
People (4)
| Name | Role | Context |
|---|---|---|
| Solit | Researcher/Doctor |
Lead researcher whose group acquired tissue samples from a patient at Memorial Sloan-Kettering; analyzed mutations re...
|
| Doroshow | Official |
Of the National Cancer Institute; commented that Solit's work 'turned on the lightbulb'.
|
| Barbara Conley | Associate Director |
Associate director of the cancer diagnosis program at NCI; leads the project to study exceptional responders.
|
| Anonymous Patient | Patient |
An 'outlier patient' who had a wonderful response to everolimus; underwent surgery at Memorial Sloan-Kettering.
|
Organizations (4)
Timeline (2 events)
Unknown (Past)
Unknown (Recent/Current in text context)
NCI project trawling archives for outlier responses among 10,000 patients
National Cancer Institute
Relationships (2)
Text mentions 'Solit's group' and surgery at Memorial Sloan-Kettering in the same context implying his affiliation.
Identified as 'associate director of the cancer diagnosis program at NCI'.
Key Quotes (4)
"“Cancer is a disease of mutations,” says Solit."Source
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Quote #1
"“It’s not surprising, in retrospect, that our patient responded really well to this specific drug,” Solit says. “She had the mutation that activated the pathway the drug targets.”"Source
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Quote #2
"Doroshow... says Solit’s work “turned on the lightbulb.”"Source
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Quote #3
"“We ought to study these people more, since we have the means now,” says Barbara Conley"Source
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Quote #4
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