HOUSE_OVERSIGHT_013713.jpg
1.99 MB
Extraction Summary
10
People
2
Organizations
0
Locations
0
Events
2
Relationships
3
Quotes
Document Information
Type:
Scientific/academic paper excerpt
File Size:
1.99 MB
Summary
This document is page 213 of a scientific paper discussing biochemical kinetics, receptor-ligand binding, and stochastic models in neuroscience. It reviews literature regarding power law kinetics and nonconvergent distributions in biological systems, citing researchers such as Mandell, Russo, and Mandelbrot. The document bears the Bates stamp 'HOUSE_OVERSIGHT_013713', indicating it is part of a document production to the House Oversight Committee, likely related to investigations into Jeffrey Epstein's connections with scientists.
People (10)
| Name | Role | Context |
|---|---|---|
| Mandell | Researcher/Author |
Cited frequently (1981, 1983, 1984, 1986); likely Arnold Mandell, a scientist associated with Epstein.
|
| Russo | Researcher/Author |
Co-author with Mandell (1981, 1984a, 1986).
|
| Knapp | Researcher/Author |
Co-author with Mandell (1983).
|
| Mandelbrot | Researcher/Author |
Cited for stochastic model work (1964) with Gerstein.
|
| Gerstein | Researcher/Author |
Cited for stochastic model work (1964) with Mandelbrot.
|
| jpnolan | Resource Owner |
Owner of the website directory listed for downloading statistical software.
|
| Sadana | Researcher |
Cited for 1998 study.
|
| Koch | Researcher |
Cited for 1991 study.
|
| Zajcek | Researcher |
Cited for 1991 study.
|
| Teich | Researcher |
Cited for multiple studies (1989, 1990, 1992, 1997).
|
Organizations (2)
| Name | Type | Context |
|---|---|---|
| American University |
Implied by the URL 'www.cas.american.edu' mentioned in the text.
|
|
| House Oversight Committee |
Indicated by the Bates stamp 'HOUSE_OVERSIGHT' at the bottom right.
|
Relationships (2)
Cited as 'Gerstein and Mandelbrot (1964)'.
Key Quotes (3)
"Similar bifurcating and power law kinetics were found in receptor-ligand binding systems (Mandell, 1984)"Source
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Quote #1
"The first demonstration of and stochastic model for nonconvergent distributions of interspike intervals of a single neuron was by Gerstein and Mandelbrot (1964)."Source
HOUSE_OVERSIGHT_013713.jpg
Quote #2
"This has not been the case for economic time series, download STABLE from http://www.cas.american.edu/~jpnolan."Source
HOUSE_OVERSIGHT_013713.jpg
Quote #3
Full Extracted Text
Complete text extracted from the document (2,390 characters)
(Mandell and Russo, 1981; Knapp and Mandell, 1983; Russo and Mandell, 1984a;
Russo and Mandell, 1986). Similar bifurcating and power law kinetics were found in
receptor-ligand binding systems (Mandell, 1984) which were confirmed by more
recent studies of diffusion-limited binding kinetics with receptors immobilized on a
biosensor surface (Sadana, 1998). Hierarchical kinetics have also been reported in
time courses of drug and metabolite levels (Koch and Zajcek, 1991), tissue tracer
washout studies (Beard and Bassingthwaighte, 1998), carrier mediated transport
processes (Ogihara et al, 1998), general pharmacokinetic functions (Macheras et al,
1996) and biochemical networks (Yates, 1992). It is likely that bifurcating and
hierarchical, power law kinetic functions will be studied more commonly in the
chemical literature in general (Shlesinger and Zaslavsky, 1996; Berlin et al, 1996)
as well as applied to a variety of protein-mediated biological functions (Dewey,
1997).
Russo and Mandell, 1986). Similar bifurcating and power law kinetics were found in
receptor-ligand binding systems (Mandell, 1984) which were confirmed by more
recent studies of diffusion-limited binding kinetics with receptors immobilized on a
biosensor surface (Sadana, 1998). Hierarchical kinetics have also been reported in
time courses of drug and metabolite levels (Koch and Zajcek, 1991), tissue tracer
washout studies (Beard and Bassingthwaighte, 1998), carrier mediated transport
processes (Ogihara et al, 1998), general pharmacokinetic functions (Macheras et al,
1996) and biochemical networks (Yates, 1992). It is likely that bifurcating and
hierarchical, power law kinetic functions will be studied more commonly in the
chemical literature in general (Shlesinger and Zaslavsky, 1996; Berlin et al, 1996)
as well as applied to a variety of protein-mediated biological functions (Dewey,
1997).
The first demonstration of and stochastic model for nonconvergent
distributions of interspike intervals of a single neuron was by Gerstein and
Mandelbrot (1964). Though rich with possibilities, it has been only very recently that
additional work from this point of view has been published. This is likely due to the
fact that most neuroscience oriented statistical packages, with rare exceptions, are
without techniques for computing descriptive parameters for these divergent
probability density distributions. This has not been the case for economic time
series, download STABLE from http://www.cas.american.edu/~jpnolan. Recently,
applications of the Fano and Allan factor as well as power spectral scaling
exponents to observed and shuffled series of spike counts and interspike intervals
in the auditory and visual systems (including spatial and/or time resolved single unit
recordings in retinal ganglion, lateral geniculate and lateral superior olivary cells as
well a auditory nerve fibers) demonstrate the characteristic behavior of
nonconvergent, hierarchical stochastic systems (Teich, 1989; Teich et al, 1990;
Lowen and Teich, 1992; Kumar and Johnson, 1993; Kelly et al, 1996; Teich et al,
1997). These statistical techniques are well suited to the characterization of the
irregularly intermittent bursting patterns generic for activity in single neurons as well
distributions of interspike intervals of a single neuron was by Gerstein and
Mandelbrot (1964). Though rich with possibilities, it has been only very recently that
additional work from this point of view has been published. This is likely due to the
fact that most neuroscience oriented statistical packages, with rare exceptions, are
without techniques for computing descriptive parameters for these divergent
probability density distributions. This has not been the case for economic time
series, download STABLE from http://www.cas.american.edu/~jpnolan. Recently,
applications of the Fano and Allan factor as well as power spectral scaling
exponents to observed and shuffled series of spike counts and interspike intervals
in the auditory and visual systems (including spatial and/or time resolved single unit
recordings in retinal ganglion, lateral geniculate and lateral superior olivary cells as
well a auditory nerve fibers) demonstrate the characteristic behavior of
nonconvergent, hierarchical stochastic systems (Teich, 1989; Teich et al, 1990;
Lowen and Teich, 1992; Kumar and Johnson, 1993; Kelly et al, 1996; Teich et al,
1997). These statistical techniques are well suited to the characterization of the
irregularly intermittent bursting patterns generic for activity in single neurons as well
213
HOUSE_OVERSIGHT_013713
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